01-P004 MicroRNAs in muscle development
نویسندگان
چکیده
منابع مشابه
01-P004 MicroRNAs in muscle development
revealed a marked reduction in radial thickness starting at E13.5, and defective postnatal cortical layering. Whereas the former was due to neuronal apoptosis starting at E12.5, which was the earliest detectable phenotype, the latter reflected dramatic impairment of neuronal differentiation. Remarkably, the primary target cells of Dicer ablation, the neuroepithelial cells, and the neurogenic pr...
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Skeletal muscle accounts for ~40% of total body mass. The principle functions of skeletal muscle include supporting the body structure, controlling motor movements and storing energy. Rhabdomyosarcoma (RMS) is a skeletal muscle‑derived soft tissue tumor widely occurring in the pediatric population. In previous years, microRNAs (miRNAs) have been demonstrated to be important in skeletal muscle d...
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Drosophila tracheal terminal branches are plastic and have the capacity to sprout-out projections towards oxygen-starved areas, in a process analogous to mammalian angiogenesis. It was previously shown that this sprouting response involves the upregulation of the FGF homolog Branchless in hypoxic tissues, which binds its receptor Breathless on tracheal cells, thereby attracting the outgrowth of...
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and ectopic expression, we demonstrated that Gata2 regulates GABAergic neuron development in the midbrain, but not in the rhombomere1. Without Gata2, all the precursors in the embryonic midbrain fail to activate GABAergic neuron-specific gene expression and switch to a glutamatergic phenotype instead. Surprisingly, this fate switch is also observed throughout the neonatal midbrain, except for t...
متن کاملNot miR-ly muscular: microRNAs and muscle development.
Precision in spatial and temporal control of gene expression is important for formation of tissues and organs. Roughly 5% of the known gene complement in animals encodes transcriptional activators and repressors, whose combinatorial action controls the expression of target genes, triggering cell-fate decisions and differentiation during development. With the discovery of microRNAs, a new means ...
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ژورنال
عنوان ژورنال: Mechanisms of Development
سال: 2009
ISSN: 0925-4773
DOI: 10.1016/j.mod.2009.06.005